Hypoxia and Cancer: Biological Implications and Therapeutic Opportunities (Cancer Drug Discovery and Development)
Price Rs. 81,080.00 (not confirmed)
Product Code:
1493953559
Weight:
1.28 lbs
Availability: In stock in the US ✔
Import from USA in Pakistan ✔
Important: Delivery of this product will take 3 to 4 weeks.
⚠️️Please Read Before Ordering
- This product price is not confirmed on our website because Amazon prices may change at any time, and currency exchange rates fluctuate regularly.
- Before confirming any order, our sales representative will share the final price, including all taxes, customs duties, government charges, freight, and local shipping. You will receive the complete doorstep price. Also salesperson will confirm product is in stock or not
- Before ordering any product, please make sure the product technically fulfills your need and contains no illegal ingredients (e.g., wine, alcohol, pig, pork, animal-based gelatin, etc.) or contents.
- In most cases, our product delivery time is 10 to 20 working days. However, in special circumstances such as weather conditions or other unforeseen delays, this timeframe may vary.
- We are not technical persons. For technical support or manufacturer's warranty of the products found on shoppingbag.pk, you can contact directly with the original manufacturer or visit their website.
- We are your importer of goods from the USA, UK, China, Russia, etc., and will not provide any technical support, product warranty, or quality check.
- Our enlarged and enhanced product pictures may differ slightly from the original products. Also, read product reviews and ratings before buying.
- We require a 30% advance on the final price, and the remaining balance is payable at the time of delivery.
- We are assuming you have read our terms & conditions and agreed with them.
Product Detail
​​​The imbalance between rapidly proliferating tumor cells and inadequate and inefficient tumor vasculature leads to a decrease in oxygen levels (hypoxia and/or anoxia) in tumor tissues. Intra-tumor hypoxia profoundly affects the biological behavior of cancer cells, which become resistant to conventional therapies and acquire a more invasive and metastatic phenotype. Hypoxia is a hallmark of the malignant phenotype and a key feature of the tumor microenvironment. Hypoxia Inducible Factor 1 (HIF-1) is a master regulator of the transcriptional response to oxygen deprivation. HIF triggers the expression of genes whose products induce angiogenesis, decrease oxygen consumption, switch metabolism to glycolysis, maintain a stem cell phenotype and select for more invasive and metastatic cells. Therapeutic approaches targeting HIF, directly or downstream mediators of its transcriptional activity, are being developed. Intra-tumor hypoxia is a topic has been gaining scientific interest over the last few years for its wide involvement in many physiological and pathological processes.ÂThis volume will cover the latest research and translational aspects associated with intra-tumor hypoxia, along with opportunities for drug development offered by this unique feature of the tumor microenvironment. The ongoing efforts to translate our understanding of the biology underlying intra-tumor hypoxia in viable therapeutic options face many challenges, but this book will provide an opportunity for an in-depth analysis of the fundamental mechanisms implicated in the adaption to low oxygen levels and will scrutinize the potential for opportunities that are being pursued in both research and the drug development industry. Binding: PaperbackEAN: 9781493953554Edition: Softcover reprint of the original 1st ed. 2014ISBN: 1493953559Label: Humana PressManufacturer: Humana PressNumberOfItems: 1NumberOfPages: 363ProductGroup: BookProductTypeName: ABIS_BOOKPublicationDate: 2016-08-23Publisher: Humana PressReleaseDate: 2016-08-23Studio: Humana PressTitle: Hypoxia and Cancer: Biological Implications and Therapeutic Opportunities (Cancer Drug Discovery and Development)
